高俊英,副教授,博士
科学研究方向
衰老与神经退行性疾病的行为与病理机制探索
联系方式
通讯:江苏省南京市江宁区龙眠大道101号人体解剖学系,邮编211166
电话:025-86869444
电邮:gaojunying@njmu.edu.cn
简介
甘肃张掖人,自2009年入职以来一直担任人体解剖学的一线教学工作。同时在江苏省神经退行性疾病重点实验室肖明课题组中开展关于衰老与神经退行性疾病的行为与病理机制探索的科研工作。于2 0 1 8 年1 2 月1 日至2 0 1 9 年8 月8 日在香港大学电子与电机工程学院生物医学图像和信号分析7 T MRI 研究实验室(laboratory of Biomedical Imaging and signal Processing 7T MRI Research lab)进行科研访学。近十年来,参与发表SCI和中文学术论文共计3 1 篇,主持并结题一项省高校青年基金和两项beat365 手机版官方网站校级项目,主持国家自然科学基金青年基金项目1项;参与1 2 项国家级和省部级的自然科学基金项目。作为审稿人受邀为“Alzheimer’s Disease & Dementia , Annals of Alzheimer's and Dementia Care , Acta Pharmacologica Sinica , Current Alzheimer Research , Neural Regeneration Research , Journal of Integrative Neuroscience , Neuroscience Bulletin 等多个杂志审稿。
教育背景及工作经历
教育经历
2014年9月-2018年7月 beat365 手机版官方网站, 人体解剖与组织胚胎学, 博士
2006年9月-2009年7月 徐州医学院, 人体解剖与组织胚胎学, 硕士
2001年9月-2006年7月 兰州大学, 预防医学, 学士
工作经历
2023年9月-至今, beat365 手机版官方网站, 江苏省神经退行性疾病重点实验室/beat365 手机版官方网站人体解剖学系, 副教授
2012年9月-2023年9月, beat365 手机版官方网站, 江苏省神经退行性疾病重点实验室/beat365 手机版官方网站人体解剖学系, 讲师
2018年12月-2019年8月, 香港大学, 工程学院生物医学影像与信号处理实验室, 副研究员
2009年9月-2012年9月, beat365 手机版官方网站, 江苏省神经退行性疾病重点实验室/beat365 手机版官方网站人体解剖学系,助教
学术兼职
江苏省解剖学会 会员
中国解剖学会 会员
承担科研课题
1.(国家自然科学基金青年项目),(胶质-脑膜淋巴通路清除老化星形胶质细胞的机制)(82204365)(30万元)(2023/01-2025/12)(在研/主持);
2.(江苏省高校自然科学面上项目),(抗氧化剂一过性延迟脑发育的机制研究)(15KJB310005)(5万元)(2015/07-2017/6)(结题/主持);
3.(国家自然科学基金面上项目),(脑膜淋巴管介导肺源性B淋巴细胞免疫应答调控5xFAD小鼠病理进程的机制研究)(82071199)(55万元)(2021/01-2024/12)(在研/参与)
4.(国家自然科学基金面上项目),(星形胶质细胞-神经元线粒体跨细胞转运失稳态介导脑衰老进程中基底前脑胆碱能退行性变的机制研究)(81871117)(56万元)(2019/01-2022/12)(结题/参与)
5.(国家自然科学基金面上项目), (AQP4调节的胶质淋巴清除功能在有氧运动延缓阿尔兹海默病进程中的作用)(81772454)(2018/01-2021/12)(58万元)(结题/参与)
6. (国家自然科学基金面上项目),(水通道蛋白-4在阿尔茨海默病进程中的作用及机制)(81271210)(2013/01-2016/12)(70万元)(结题/参与)。
代表性论文
1.Wang T, Chen Y, Zou Y, Pang Y, He X, Chen Y, Liu Y, Feng W, Zhang Y, Li Q, Shi J, Ding F, Marshall C, Gao J*, Xiao M*. Locomotor Hyperactivity in the Early-Stage Alzheimer's Disease-like Pathology of APP/PS1 Mice: Associated with Impaired Polarization of Astrocyte Aquaporin 4. Aging Dis 2022;13:1504-1522. doi: 10.14336/AD.2022.0219
2.Zhang Y, Pang Y, Feng W, Jin Y, Chen S, Ding S, Wang Z, Zou Y, Li Y, Wang T, Sun P, Gao J, Zhu Y, Ke X, Marshall C, Huang H, Sheng C, Xiao M. miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex. Cell Mol Life Sci 2022;79:507. doi: 10.1007/s00018-022-04533-6
3.Li Q, Chen Y, Feng W, Cai J, Gao J, Ge F, Zhou T, Wang Z, Ding F, Marshall C, Sheng C, Zhang Y, Sun M, Shi J, Xiao M. Drainage of senescent astrocytes from brain via meningeal lymphatic routes. Brain Behav Immun 2022;103:85-96. doi: 10.1016/j.bbi.2022.04.005
4.Feng W, Zhang Y, Wang Z, Xu H, Wu T, Marshall C, Gao J*, Xiao M*. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance. Alzheimers Res Ther 2020;12:125. doi: 10.1186/s13195-020-00688-1
5.Gao JY, Chen Y, Su DY, Marshall C, Xiao M. Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress. Behav Brain Res 2018;353:114-123. doi: 10.1016/j.bbr.2018.07.007
6.Huang H, Nie S, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M. Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice. Age (Dordr) 2016;38:303-322. doi: 10.1007/s11357-016-9929-7
7.Chen YL, Wang LM, Chen Y, Gao JY, Marshall C, Cai ZY, Hu G, Xiao M. Changes in astrocyte functional markers and beta-amyloid metabolism-related proteins in the early stages of hypercholesterolemia. Neuroscience 2016;316:178-191. doi: 10.1016/j.neuroscience.2015.12.039
8.Huang H, Wang L, Cao M, Marshall C, Gao J, Xiao N, Hu G, Xiao M. Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice. Int J Neuropsychopharmacol 2015;18:pyu116. doi: 10.1093/ijnp/pyu116
9.Yuan C, Gao J, Guo J, Bai L, Marshall C, Cai Z, Wang L, Xiao M. Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PLoS One 2014;9:e107447. doi: 10.1371/journal.pone.0107447
10.Wu Q, Zhang YJ, Gao JY, Li XM, Kong H, Zhang YP, Xiao M, Shields CB, Hu G. Aquaporin-4 mitigates retrograde degeneration of rubrospinal neurons by facilitating edema clearance and glial scar formation after spinal cord injury in mice. Mol Neurobiol 2014;49:1327-1337. doi: 10.1007/s12035-013-8607-3
11.Hao L, Huang H, Gao J, Marshall C, Chen Y, Xiao M. The influence of gender, age and treatment time on brain oxidative stress and memory impairment induced by D-galactose in mice. Neurosci Lett 2014;571:45-49. doi: 10.1016/j.neulet.2014.04.038
12.Gu M, Shen L, Bai L, Gao J, Marshall C, Wu T, Ding J, Miao D, Xiao M. Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging. Age (Dordr) 2014;36:129-139. doi: 10.1007/s11357-013-9552-9
13.Xu ZQ, Zhang LQ, Wang Q, Marshall C, Xiao N, Gao JY, Wu T, Ding J, Hu G, Xiao M. Aerobic exercise combined with antioxidative treatment does not counteract moderate- or mid-stage Alzheimer-like pathophysiology of APP/PS1 mice. CNS Neurosci Ther 2013;19:795-803. doi: 10.1111/cns.12139
14.Wei S, Xu Z, Gao J, Ding J, Xiao M. Prenatal ethanol exposure does not cause neurological alterations in adult CD1 mice. Neuroreport 2013;24:196-201. doi: 10.1097/WNR.0b013e32835e3258
15.Wang Q, Xu Z, Tang J, Sun J, Gao J, Wu T, Xiao M. Voluntary exercise counteracts Abeta25-35-induced memory impairment in mice. Behav Brain Res 2013;256:618-625. doi: 10.1016/j.bbr.2013.09.024
16.Liu XL, Lu YS, Gao JY, Marshall C, Xiao M, Miao DS, Karaplis A, Goltzman D, Ding J. Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms. Mol Neurobiol 2013;48:590-600. doi: 10.1007/s12035-013-8448-0
17.Li X, Gao J, Ding J, Hu G, Xiao M. Aquaporin-4 expression contributes to decreases in brain water content during mouse postnatal development. Brain Res Bull 2013;94:49-55. doi: 10.1016/j.brainresbull.2013.02.004
18.Yang W, Wu Q, Yuan C, Gao J, Xiao M, Gu M, Ding J, Hu G. Aquaporin-4 mediates astrocyte response to beta-amyloid. Mol Cell Neurosci 2012;49:406-414. doi: 10.1016/j.mcn.2012.02.002
19.Liu L, Lu Y, Kong H, Li L, Marshall C, Xiao M, Ding J, Gao J, Hu G. Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection. Int J Neuropsychopharmacol 2012;15:55-68. doi: 10.1017/S1461145711000022
20.Li L, Xiao N, Yang X, Gao J, Ding J, Wang T, Hu G, Xiao M. A high cholesterol diet ameliorates hippocampus-related cognitive and pathological deficits in ovariectomized mice. Behav Brain Res 2012;230:251-258. doi: 10.1016/j.bbr.2012.02.024
21.Gao J, Tan M, Gu M, Marshall C, Ding J, Hu G, Xiao M. Cellular localization of aquaporin-1 in the human and mouse trigeminal systems. PLoS One 2012;7:e46379. doi: 10.1371/journal.pone.0046379
22.Cao G, Gu M, Zhu M, Gao J, Yin Y, Marshall C, Xiao M, Ding J, Miao D. Bmi-1 absence causes premature brain degeneration. PLoS One 2012;7:e32015. doi: 10.1371/journal.pone.0032015
23.Wu W, Li M, Liu L, Gao J, Kong H, Ding J, Hu G, Xiao M. Astrocyte activation but not neuronal impairment occurs in the hippocampus of mice after 2 weeks of d-galactose exposure. Life Sci 2011;89:355-363. doi: 10.1016/j.lfs.2011.06.028
24.Li L, Ding J, Marshall C, Gao J, Hu G, Xiao M. Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus D-galactose-injected mice. Behav Brain Res 2011;217:244-247. doi: 10.1016/j.bbr.2010.10.032
25.Liu L, Su Y, Yang W, Xiao M, Gao J, Hu G. Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience 2010;169:596-608. doi: 10.1016/j.neuroscience.2010.05.028
26.高俊英,韦素丽,肖明,韩群颖,丁炯*, 去除窦弓神经引起下丘脑室旁核小细胞部氮能神经元持续激活(英文),神经解剖学杂志, 2011,5:515~520
27.高俊英,朱永红,张露青,肖明,丁炯*,自发性高血压大鼠脑干心血管核团内星形胶质细胞的活化,解剖学研究 2011,3:183-185
28.蔡倩倩,高俊英*,谭美芸,肖明,水通道蛋白1在哺乳动物体内的分布及功能,解剖科学进展,2012,5:469-472
29.谭美芸,高俊英,肖明*, 禁水后小鼠三叉神经节AQP1和AQP4表达的改变,江苏医药,2011;22:2616~2617
30.谭美芸,高俊英,丁炯,肖明*,水通道蛋白1在小鼠口腔粘膜表达与分布,解剖科学进展,2011;5:458~460
31.张伟,高俊英,许晶,崔桂云, 幼年大鼠脑室下区N-甲基-D-天冬氨酸受体亚单位2B的表达及其细胞类型,中国组织工程研究, 2012;1:116~120