苏川

苏川，教授，医学博士，博士生导师，beat365 手机版官方网站院长

科学研究方向 感染免疫学 

联系方式

通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166

电话：025－86869328

电邮：chuansu@njmu.edu.cn

简介

       苏川，1993年7月本科毕业于beat365 手机版官方网站临床医学系并获医学学士学位，1998年7月研究生毕业于beat365 手机版官方网站病原生物学专业并获医学博士学位。2001年1月至2003年12月在美国Rochester大学进行肿瘤发展与免疫调控方面的博士后研究。现在为beat365 手机版官方网站院长，病原生物学系教授、博士研究生导师，江苏省现代病原生物学重点实验室主任。入选江苏省“青蓝工程”优秀青年学术带头人、江苏省“333工程”和“六大人才高峰”人才培养计划。

      主要从事感染免疫应答调控的相关研究工作。主持国家自然科学基金重点与面上项目、国家“863计划”重大专项、科技部重点研发计划课题等。共发表论文150多篇，其中主要以通讯作者在Nature Communications、PLoS Pathogens、EMBO J、Aging cell、Eur J Immunol、PLoS NTD、Vaccine、Microbes Infect等杂志发表SCI论文30多篇。近年的研究成果共获得省部级奖4项，授权和申报国家发明专利共4项。共同主编人民卫生出版社五年制临床医学国家规划教材《人体寄生虫学》第八版、第九版，副主编人民卫生出版社长学制临床医学国家规划教材《人体寄生虫学》第三版。

教育背景及工作经历

1988.09－1993.07     beat365 手机版官方网站(原称南京医学院)临床医学系，本科/学士

1993.09－1998.07     beat365 手机版官方网站病原生物学系，(1995年硕转博连读)研究生/博士

1998.08－2000.12     beat365 手机版官方网站病原生物学系，讲师

2001.01－2003.12     美国University of Rochester，Medical Center，博士后

2004.01－2007.07     beat365 手机版官方网站病原生物学系副主任，副教授，博士研究生导师

                                  江苏省现代病原生物学重点实验室副主任

2007.09－至今           beat365 手机版官方网站病原生物学系教授

2008.04－至今           江苏省现代病原生物学重点实验室主任

2009.02－2012.06     beat365 手机版官方网站病原生物学系主任

2012.06－2017.01     beat365 手机版官方网站副院长，基础医学实验教学中心主任

2017.02－2018.02     beat365 手机版官方网站人事处长

2018.02－至今           beat365 手机版官方网站院长

奖项及荣誉

“日本血吸虫病疫苗的免疫学与生物学基础研究”获国家教育部2010年度高等学校科学研究优秀成果奖（自然科学奖）二等奖　2010年　1/11

“医学教育的信息化流程再造”获2017年江苏省教学成果奖（高等教育类）特等奖 2017年9月  江苏省教育厅2/5

“信息技术与医学教育深度融合的创新实践”获2018年高等教育国家级教学成果奖二等奖2018年12月  国家教育部 4/17

编写教材及课程主持情况

共同主编国内首部“人体寄生虫学”数字教材（人民卫生出版社）

共同主编人民卫生出版社五年制临床医学国家规划教材《人体寄生虫学》第八版

共同主编人民卫生出版社五年制临床医学国家规划教材《人体寄生虫学》第九版

副主编人民卫生出版社长学制临床医学国家规划教材《人体寄生虫学》第三版

“医学形态实验学”课程负责人，国家级精品资源共享课（2013年）

学术兼职

中华预防医学会医学寄生虫分会第五届常务委员、第六届江苏省热带病与寄生虫学分会副主任委员、江苏省动物学会寄生虫学专业分会主任委员、江苏省动物学会理事、江苏省微生物与免疫学会理事。

承担科研课题

近五年代表性论文

1.    1. Liyang Dong, Yanan Pu, Xiaojun Chen, Xin Qi, Lina Zhang, Lei Xu, Wei Li, Yongbin Ma, Sha Zhou, Jifeng Zhu, Yalin Li, Xuefeng Wang and Chuan Su*. hUCMSC- extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S.japonicum-infected mice. Stem Cell Res Ther 2020,9;11(1):21. doi: 10.1186/s13287-019-1539-8

2. Xiaojun Chen, Zhipeng Xu, Chuan Wei, XiaoWei Yang, Lei Xu, Sha Zhou, Jifeng Zhu, Chuan Su*. Follicular helper T cells recruit eosinophils into host liver by producing CXCL12 during Schistosoma japonicum infection.  J Cell Mol Med. 2020;24:2566–2572

3. Ying Wang, Liyang Dong, Hai Zhong, Linfei Yang, Qian Li, Chuan Su*, Wei Gu*, and Yingying Qian*. Extracellular Vesicles (EVs) from Lung Adenocarcinoma Cells Promote Human Umbilical Vein Endothelial Cell (HUVEC) Angiogenesis through Yes Kinase-associated Protein (YAP) Transport.  Int J Biol Sci. 2019;15(10):2110-2118

4. Xue Xue, Weiwei Zhang, Jifeng Zhu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Gang Hu, Chuan Su*. Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.  J Cell Mol Med. 2019;23(4):2568-2582

5. Yanqiu Yu, Cheng Fang, Chunyan Peng, ShanshanShen, Guifang Xu, Qi Sun, Lin Li, Chuan Su*, Xiaoping Zou*.  Risk factors for gastric intraepithelial neoplasia in Chinese adults: a case–control study.  Cancer Management and Research 2018:10 2605–2613

6. Lei Xu^#, Wei Li^#, Xiaofan Wang, Lina Zhang, Qianqian Qi, Liyang Dong, Chuan Wei, Yanan Pu, Yalin Li, Jifeng Zhu, Sha Zhou, Feng Liu, Xiaojun Chen* and Chuan Su*. The IL-33-ST2-MyD88 axis promotes regulatory T cell proliferation in the murine liver.   Eur. J. Immunol. 2018. 48: 1302–1307

7. Liyang Dong^#, Yanan Pu, Lina Zhang, Qianqian Qi, Lei Xu, Wei Li, Chuan Wei, Xiaofan Wang, Sha Zhou,Jifeng Zhu, Xuefeng Wang, Feng Liu, Xiaojun Chen^*, and Chuan Su^*. Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410.  Cell Death Dis. 2018; 9(2):218. doi: 10.1038/s41419-018-0323-5

8. Lei He^#, Sha Zhou^#, Qianqian Qi, Ying Chi, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Jason Hoellwarth, Feng Liu, Xiaojun Chen^*, and Chuan Su^*.  The regulation of regulation: IL-10 increases CD4⁺CD25⁺regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma.Immunology. 2018 ;153(1): 84-96

9. Sha Zhou^#, Qianqian Qi, Xiaofan Wang, Lina Zhang, Lei Xu, Liyang Dong, Jifeng Zhu, Yalin Li, Xuefeng Wang, Zhipeng Xu, Feng Liu, Wei Hu, Liang Zhou, Xiaojun Chen^*, and Chuan Su^*. SjHSP60 induces CD4+CD25+ Foxp3+ Tregs via TLR4-Mal-drived production of TGF-β in macrophages.  Immunol Cell Biol. 2018;96(9):958-968

10. Jifeng Zhu^#, Weiwei Zhang, Lina Zhang, Lei Xu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Ming Xiao, Hui Bai, Feng Liu, Chuan Su^*.  IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum-infected mice.  J Cell Mol Med. 2018;22(7):3353-3363

11. Xiancheng Dong, Bin Lv, YusongLi, QinghuaCheng, Chuan Su^*, GuoyongYin^*. MiR-143 regulates the proliferation and migration of osteosarcoma cells through targeting MAPK7.  Archives of Biochemistry and Biophysics. 2017, 630:47-53. doi: 10.1016/j.abb. 2017.07.011.

12. Xiaojun Chen,Wei Li,Yalin Li,Lei Xu,Sha Zhou,Jifeng Zhu,Zhipeng Xu^*,Feng Liu,Dandan Lin,Fei Hu,Yuemin Liu,Wen Jiang,Liwang Cui,Chuan Su^*. Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis. Scientific Reports. 2017, 7(1):7765. doi: 10.1038/s41598-017-08283-5.

13. Zhipeng Xu, Lei Xu , Wei Li, Xin Jin, Xian Song, Xiaojun Chen^*, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, and Chuan Su^*. Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection.  Nature Communications 2017,8:16035. doi: 10.1038/ ncomms16035.

14. Ying Chi⁺, Yiyue Ge⁺, Kangchen Zhao, Bingjie Zou, Bin Liu, Xian Qi, Qian Bian, Zhiyang Shi, Fengcai Zhu, Minghao Zhou, Lunbiao Cui^*, Chuan Su*Multiplex Reverse- Transcription Loop-Mediated Isothermal Amplification Coupled with Cascade Invasive Reaction and Nanoparticle Hybridization for Subtyping of Influenza A Virus. Scientific Reports. 2017,21;7:44924. doi: 10.1038/srep44924

15. Xiaoyun Yu, Jingang An, Yunhui Hua, Zihai Li, Ning Yan, Weixin Fan*, Chuan Su* MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis. Pathology Research and Practice 2017 Feb;213(2):89-97

16. Jing Sun†, Run Shi†, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma*, Chuan Su*E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle.  Journal of Experimental & Clinical Cancer Research 2017,7;36(1):40. doi: 10.1186/s13046-017-0504-6.

17. Sha Zhou, Xin Jin, Yalin Li, Wei Li, Xiaojun Chen, Lei Xu, Jifeng Zhu, Zhipeng Xu, Yang Zhang, Feng Liu, Chuan Su*Blockade of PD-1 signaling enhances Th2 cell responses and aggravates liver immunopathology in mice with Schistosomiasis japonica. PLoS NTD 2016 DOI:10.1371/journal.pntd.0005094

18. Xiaowei Wang, Xiaojun Chen, Heng Tang, Jifeng Zhu, Sha Zhou, Zhipeng Xu, Feng Liu, and Chuan Su*.  Increased Frequency of Th17 Cells in Children with Mycoplasma pneumoniae Pneumonia.  Journal of Clinical Laboratory Analysis 2016, 00: 1–6. doi: 10.1002/jcla.22005.

19. Sha Zhou, Xin Jin, Xiaojun Chen, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Feng Liu, Wei Hu, Liang Zhou, Chuan Su*Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis japonica.  PLoS ONE 2015; 10(9): e0139133. doi: 10.1371/journal.pone.0139133

20. Xiaojun Chen, Wei Li, Yang Zhang, Xian Song, Lei Xu, Zhipeng Xu, Sha Zhou, Jifeng Zhu, Xin Jin, Feng Liu, Gengxin Chen, Chuan Su*  Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.  PLoS NTD 2015, 9(8):e0004015. doi: 10.1371/journal.pntd.0004015

21. Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su* An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum. Parasites and Vectors 2015, 8(1): 37  DOI: 10.1186/s13071-015-0650-7

22. Sha Zhou, Xiaoxiao Dong, Cui Zhang, Xiaojun Chen, Jifeng Zhu, Wei Li, Xian Song, Zhipeng Xu, Weiwei Zhang, Xiaowei Yang, Yong Li, Feng Liu, Chuan Su*.  MicroRNAs are implicated in the suppression of CD4⁺CD25^- conventionalT cell proliferation by CD4⁺CD25⁺ regulatory T cells.  Molecular Immunology 2015, 63: 464-472

23. Xiaojun Chen, Xiaowei Yang, Yong Li, Jifeng Zhu, Sha Zhou,Zhipeng Xu, Lei He, Xue Xue,Weiwei Zhang, Xiaoxiao Dong, Henry Wu, Carrie J Li, Hsiang-Ting Hsu, Wenjun Kong, Feng Liu, Prem B. Tripathi, Michelle S. Yu, Jason Chang, Liang Zhou, Chuan Su*.  Follicular Helper T Cells Promote Liver Pathology in Miceduring Schistosoma japonicum Infection.  PLoS Pathogens 2014, 10(5): e1004097. doi:10.1371/ journal. ppat.1004097 

24. Jifeng Zhu, Zhipeng Xu, Xiaojun Chen, Sha Zhou, Weiwei Zhang, Ying Chi, Wei Li, Xian Song, Feng Liu, Chuan Su*.   Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice.  Parasites and Vectors 2014,7:122 DOI: 10.1186/1756-3305-7-122 

25. Yang Dai, Xiaoting Wang, Song Zhao, Jianxia Tang, Lu Zhang, Yinchang Zhu, Jianrong Dai, Mingtao Zeng, Shan Lu, Chuan Su*.Construction and evaluation of replication- defective recombinant optimized triosephosphateisomerase adenoviral vaccination in Schistosoma japonicum challenged mice.  Vaccine 2014, 32(7): 771-778

1